All polymorphisms studied in this paper [PMID: 19242068] , total : 5 polymorphisms

Title : Genetic polymorphisms modifying oxidative stress are associated with disease activity in rheumatoid arthritis patients.

Abstract : Reactive oxygen and nitrogen species are involved in the pathology of rheumatoid arthritis (RA). Polymorphisms in genes coding for superoxide dismutases (SOD2 and SOD3), catalase (CAT), tumor necrosis factor-alpha (TNFA) and inducible NO synthase (NOS2A) may influence RA activity. We determined SOD2 Ala-9Val, SOD3 Arg213Gly, CAT C-262T, TNFA G-308A, TNFA C-857T and NOS2A (CCTTT) (n)polymorphisms in 327 RA patients. Carriers of CAT -262T and TNFA -308A allele had lower mean disease activity score of 28 joint count (DAS28) values than patients with CAT -262CC and TNFA -308GG genotypes (p = 0.014 and p = 0.046, respectively). Patients with the combination of CAT -262T and TNFA -308A allele had lower mean DAS28 values and a higher probability for low disease activity than non-carriers (p = 0.003, OR = 3.585, 95% CI = 1.538-8.357). Our results suggest that CAT and TNFA polymorphisms alone and in combination influence the activity of RA.

Author : Bohanec Grabar P,Logar D,Tomsic M,Rozman B,Dolzan V,

Source : Dis Markers. 2009;26(1):41-8. doi: 10.3233/DMA-2009-0603.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	NA	SOD2	6648
2	NA	CAT	847
3	rs1800629	TNF	7124
4	rs1799724	TNF	7124
5	NA	NOS2	4843