All polymorphisms studied in this paper [PMID: 19503088] , total : 7 polymorphisms

Title : REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.

Abstract : We conducted a genome-wide association study of rheumatoid arthritis in 2,418 cases and 4,504 controls from North America and identified an association at the REL locus, encoding c-Rel, on chromosome 2p13 (rs13031237, P = 6.01 x 10(-10)). Replication in independent case-control datasets comprising 2,604 cases and 2,882 controls confirmed this association, yielding an allelic OR = 1.25 (P = 3.08 x 10(-14)) for marker rs13031237 and an allelic OR = 1.21 (P = 2.60 x 10(-11)) for marker rs13017599 in the combined dataset. The combined dataset also provides definitive support for associations at both CTLA4 (rs231735; OR = 0.85; P = 6.25 x 10(-9)) and BLK (rs2736340; OR = 1.19; P = 5.69 x 10(-9)). c-Rel is an NF-kappaB family member with distinct functional properties in hematopoietic cells, and its association with rheumatoid arthritis suggests disease pathways that involve other recently identified rheumatoid arthritis susceptibility genes including CD40, TRAF1, TNFAIP3 and PRKCQ.

Author : Gregersen PK,Amos CI,Lee AT,Lu Y,Remmers EF,Kastner DL,Seldin MF,Criswell LA,Plenge RM,Holers VM,Mikuls TR,Sokka T,Moreland LW,Bridges SL Jr,Xie G,Begovich AB,Siminovitch KA,

Source : Nat Genet. 2009 Jul;41(7):820-3. doi: 10.1038/ng.395. Epub 2009 Jun 7.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs13031237	REL	5966
2	rs13017599	REL	5966
3	rs231735	NA	NA
4	rs2736340	NA	NA
5	rs2476601	PTPN22	26191
6	rs881375	PHF19	26147
7	rs6748358	NA	NA