All polymorphisms studied in this paper [PMID: 19662331] , total : 22 polymorphisms

Title : Association of 22 cytokine gene polymorphisms with rheumatoid arthritis in population of ethnic Macedonians.

Abstract : To examine the possible role of 22 cytokine gene polymorphisms in host susceptibility to or protection against RA in Macedonians. In this study, 301 healthy unrelated individuals and 85 patients with RA were studied. Cytokine genotyping was performed by PCR with sequence-specific priming (PCR-SSP) (Heidelberg kit). Results showed susceptible association for four cytokine alleles, six cytokine genotypes, one haplotype, and four combinations of haplotypes, while protective associations were found for four cytokine alleles, three cytokine genotypes, three haplotypes, and only one combination of haplotypes. These results suggest that IL-4 -1098, IL-4 -590, IL-10 -1082, IL-10 -819, IL-2 -330, IL-6 -174, and TNF-alpha -238 cytokine gene polymorphisms might be significantly associated and affect host susceptibility and/or resistance to RA in Macedonians.

Author : Trajkov D,Mishevska-Perchinkova S,Karadzova-Stojanoska A,Petlichkovski A,Strezova A,Spiroski M,

Source : Clin Rheumatol. 2009 Nov;28(11):1291-300. doi: 10.1007/s10067-009-1238-4. Epub 2009 Aug 7.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	NA	IL1A	3552
2	rs16944	IL1B	3553
3	NA	IL1B	3553
4	NA	IL1R1	3554
5	NA	IL1R1	3554
6	NA	IL4R	3566
7	NA	IL12A	3592
8	NA	IFNG	3458
9	NA	TGFB1	7040
10	NA	TGFB1	7040
11	rs1800629	TNF	7124
12	rs361525	TNF	7124
13	NA	IL2	3558
14	NA	IL2	3558
15	NA	IL4	3565
16	rs2243250	IL4	3565
17	NA	IL4	3565
18	rs1800795	IL6	3569
19	NA	IL6	3569
20	rs1800896	IL10	3586
21	rs3021097	IL10	3586
22	NA	IL10	3586