All polymorphisms studied in this paper [PMID: 19714582] , total : 10 polymorphisms

Title : Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors.

Abstract : OBJECTIVE: Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) share some genetic factors such as HLA, PTPN22, STAT4, and 6q23. The aim of this study was to determine whether 9 other SLE genetic factors are also implicated in RA susceptibility. METHODS: A characteristic single-nucleotide polymorphism (SNP) in each of 9 genetic factors, ITGAM (rs1143679), C8orf13-BLK (rs13277113), TYK2 (rs2304256), 1q25.1 (rs10798269), PXK (rs6445975), KIAA1542 (rs4963128), MECP2 (rs17435), BANK1 (rs17266594), and LY9 (rs509749), was studied in 1,635 patients with RA and 1,906 control subjects from Spain. The rs7574865 SNP in STAT4 was also included. Analyses were conducted globally and after stratification by sex and clinical features (anti-cyclic citrullinated peptide and rheumatoid factor, shared epitope, rheumatoid nodules, radiographic changes, sicca syndrome, and pneumonitis). RESULTS: No association was observed between RA and any of the 9 newly identified SLE genetic factors. A meta-analysis using previous data was consistent with these results. In addition, there were no significant differences between individuals with and those without each of the clinical features analyzed, except the frequency of the minor allele in the C8orf13-BLK locus that was decreased in patients with sicca syndrome (14.6% versus 22.4% in controls; P = 0.003). CONCLUSION: None of the 9 recently identified SLE risk factors showed association with RA. Therefore, common genetic factors affecting the pathogenesis of these 2 disorders seem to be limited, revealing that the genetic component contributes to the different expression of these diseases.

Author : Suarez-Gestal M,Calaza M,Dieguez-Gonzalez R,Perez-Pampin E,Pablos JL,Navarro F,Narvaez J,Marenco JL,Herrero-Beaumont G,Fernandez-Gutierrez B,Lamas JR,de la Serna AR,Ortiz AM,Carreno L,Canete JD,Caliz R,Blanco FJ,Balsa A,Gomez-Reino JJ,Gonzalez A,

Source : Arthritis Rheum. 2009 Sep;60(9):2558-64. doi: 10.1002/art.24748.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs7574865	STAT4	6775
2	rs1143679	ITGAM	3684
3	rs13277113	BLK	640
4	rs2304256	TYK2	7297
5	rs10798269	LOC100506023	100506023
6	rs4963128	PHRF1	57661
7	rs6445975	PXK	54899
8	rs17266594	BANK1	55024
9	rs509749	NA	NA
10	rs17435	MECP2	4204