All polymorphisms studied in this paper [PMID: 19758192] , total : 4 polymorphisms

Title : Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.

Abstract : Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL-10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL-10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid arthritis (RA), a total of 144 RA patients were recruited into the study. We found significant differences in genotype distribution of the -1082G/A polymorphism between IgG, IgA, and IgM rheumatoid factor(RF)-positive/negative RA patients. We also found significant differences in allelic frequencies of the -3575T/A, -819C/T, and -592A/C polymorphisms between anticyclic citrullinated peptide (anti-CCP)-positive/negative RA patients. The haplotype TGAATA was found to be less frequent within anti-CCP-positive RA patients. Results obtained in this study provide evidence of an association between polymorphisms in IL-10 gene promoter and the production of autoantibodies in RA patients.

Author : Nemec P,Goldbergova MP,Gatterova J,Vasku A,Soucek M,

Source : Ann N Y Acad Sci. 2009 Sep;1173:501-8. doi: 10.1111/j.1749-6632.2009.04625.x.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs1800896	IL10	3586
2	NA	IL10	3586
3	rs3021097	IL10	3586
4	NA	IL10	3586