All polymorphisms studied in this paper [PMID: 20113255] , total : 15 polymorphisms

Title : Association of the CD28/CTLA4/ICOS polymorphisms with susceptibility to rheumatoid arthritis.

Abstract : BACKGROUND: Rheumatoid arthritis (RA) is currently thought to be an immune-mediated disease where the host's genes and environmental factors interact. Some of the immuno-regulatory genes that are responsible for an individual's susceptibility to RA have been identified. The co-stimulatory receptor gene cluster on chromosome 2q33 encodes for both the positive T-cell regulators CD28 molecule (CD28) and inducible T-cell co-stimulator (ICOS), and the negative regulator cytotoxic T-lymphocyte-associated protein 4 (CTLA4). The CTLA4 gene has been implicated in several immune-mediated diseases, but it is not known whether RA is associated with any of these genes. METHODS: We conducted single nucleotide polymorphism (SNP) genotyping with direct sequencing and restriction fragment length polymorphism for 308 Korean patients with RA and 412 healthy control subjects. For the case-control analysis, SNPStats, SNPAnalyzer and Helixtree programs were used. RESULTS: Although none of the polymorphisms in CTLA4 showed a significant association with RA, CD28 and ICOS showed a significant association with RA [rs2140148 in CD28, p = 0.022, odds ratio (OR) = 1.60, 95% confidence interval (CI) = 1.07-2.40 in the dominant model, rs6726035 in ICOS, p = 0.032, OR = 1.28, 95% CI = 1.02-1.60 in the codominant model]. CONCLUSIONS: Our results suggest that CD28 and ICOS genes may be associated with a risk of RA in Koreans.

Author : Kim YO,Kim HJ,Kim SK,Chung JH,Hong SJ,

Source : Clin Chem Lab Med. 2010 Mar;48(3):345-53. doi: 10.1515/CCLM.2010.074.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs1879877	CD28	940
2	rs3181097	CD28	940
3	rs2140148	CD28	940
4	rs3116494	CD28	940
5	rs231777	CTLA4	1493
6	rs231779	CTLA4	1493
7	rs4270326	ICOS	29851
8	rs11571314	ICOS	29851
9	rs10183087	ICOS	29851
10	rs4404254	ICOS	29851
11	rs1559931	ICOS	29851
12	rs1365828	NA	NA
13	rs4675415	NA	NA
14	rs768180	NA	NA
15	rs6726035	NA	NA