All polymorphisms studied in this paper [PMID: 20138855] , total : 1 polymorphisms

Title : The +49A>G CTLA-4 polymorphism is associated with rheumatoid arthritis in Mexican population.

Abstract : BACKGROUND: The Cytotoxic T lymphocyte antigen (CTLA-4) is one of the major susceptibility genes associated with autoimmune diseases. Susceptibility to rheumatoid arthritis (RA) is determined by both environmental and genetic factors. The genetic contribution approaches 50-60%. The association between RA with the +49A>G CTLA-4 polymorphism in the Mexican population was investigated. METHODS: The polymerase chain reaction-restriction fragment was used to amplify the +49A>G CTLA-4 polymorphism in RA patients and healthy subjects (HS). RESULTS: We analyzed the association between the +49A>G CTLA-4 polymorphism and RA. The G allele frequency was higher in RA patients than HS (46.8 vs 37.7%, OR=1.45, p=0.01). RA patients carrying the A/G genotype were significantly more likely to be positive to CRP and RF. There was no evidence of an association between SNP genotypes and the clinical characteristics of rheumatoid arthritis. CONCLUSIONS: The +49A>G CTLA-4 polymorphism is a genetic marker of susceptibility for RA in western Mexican population.

Author : Munoz-Valle JF,Valle Y,Padilla-Gutierrez JR,Parra-Rojas I,Rangel-Villalobos H,Vazquez del Mercado M,Ledezma-Lozano IY,Villafan-Bernal JR,Armendariz-Borunda J,Pereira-Suarez AL,

Source : Clin Chim Acta. 2010 May 2;411(9-10):725-8. doi: 10.1016/j.cca.2010.02.001. Epub 2010 Feb 6.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs231775	CTLA4	1493