All polymorphisms studied in this paper [PMID: 20401725] , total : 7 polymorphisms

Title : Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom.

Abstract : Genetic associations of TNFR2, VDR (Bsm I and Fok I), A2M, GSTT(1), GSTM(1) and ACE in South Asian and Caucasian patients with rheumatoid arthritis (RA) were assessed in this study. DNA samples from South Asians (134 cases, 149 controls) and Caucasians (137 cases, 150 controls) from the East Midlands of the United Kingdom were genotyped for seven polymorphisms. All cases were rheumatoid-factor positive. Significant genetic associations were observed with TNFR2 R-R (OR = 3.16, CI 1.20-9.26, P < 0.05), A2M 1-1 (OR = 2.09, CI 1.21-3.64, P < 0.05) and GST T(1)null (OR = 1.97, CI 1.07-3.68, P < 0.05) among Caucasian patients. In South Asians, VDR Bsm I B-B genotype (OR = 2.08, CI 1.23-3.52, P < 0.05), A2M 2-2 genotype (OR = 3.99, CI 1.19-17.18, P < 0.05), and GST T(1)null genotype (OR = 2.81, CI 1.40-5.77, P < 0.002) genotypes were associated with RA. In the majority of cases, recessive and multiplicative modes of inheritance explained the observed associations. This study demonstrates that ethnicity affects the genetic associations in RA.

Author : Ghelani AM,Samanta A,Jones AC,Mastana SS,

Source : Rheumatol Int. 2011 Oct;31(10):1355-61. doi: 10.1007/s00296-010-1478-2. Epub 2010 Apr 18.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs1061622	TNFRSF1B	7133
2	rs1544410	VDR	7421
3	rs2228570	VDR	7421
4	rs3832852	A2M	2
5	NA	ACE	1636
6	NA	GSTK1	373156
7	NA	GSTK1	373156