All polymorphisms studied in this paper [PMID: 20444755] , total : 17 polymorphisms

Title : Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.

Abstract : BACKGROUND: Anti-tumour necrosis factor (anti-TNF) therapy has proved to be highly successful in treating rheumatoid arthritis (RA), although 30-40% of patients have little or no response. The authors hypothesise that this may be genetically determined. In other complex diseases, susceptibility genes have been shown to influence treatment response. The aim of the current study was to investigate the association of markers within confirmed RA susceptibility loci with the response to anti-TNF treatment. METHODS: Eighteen single nucleotide polymorphisms (SNPs) mapping to 11 genetic loci were genotyped in 1012 patients with RA receiving treatment with etanercept, infliximab or adalimumab. Multivariate linear regression analyses were performed using the absolute change in 28 joint count disease activity score (DAS28) between baseline and 6-month follow-up as the outcome variable, adjusting for confounders. p Values <0.05 were considered statistically significant and associated markers were genotyped in an additional 322 samples. Analysis was performed in the combined cohort of 1334 subjects with RA treated with anti-TNF. RESULTS: In the combined analysis, SNPs mapping to AFF3 and CD226 had a statistically significant association with the response to anti-TNF treatment under an additive model. The G allele at rs10865035, mapping to AFF3, was associated with an improved response to anti-TNF treatment (coefficient -0.14 (95% CI -0.25 to -0.03), p=0.015). At the CD226 SNP rs763361, the C allele conferred reduced response to treatment (coefficient 0.11 (95% CI 0.00 to 0.22), p=0.048). CONCLUSION: These results suggest that AFF3 and CD226, two confirmed RA susceptibility genes, have an additional role in influencing the response to anti-TNF treatment.

Author : Tan RJ,Gibbons LJ,Potter C,Hyrich KL,Morgan AW,Wilson AG,Isaacs JD,Barton A,

Source : Ann Rheum Dis. 2010 Jun;69(6):1029-35. doi: 10.1136/ard.2009.118406. Epub 2010 May 5.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs10865035	LINC01104	150577
2	rs763361	CD226	10666
3	rs1160542	LINC01104	150577
4	rs7574865	STAT4	6775
5	rs10181656	STAT4	6775
6	rs231775	CTLA4	1493
7	rs3087243	CTLA4	1493
8	rs6822844	NA	NA
9	rs13192841	NA	NA
10	rs6920220	NA	NA
11	rs5029937	TNFAIP3	7128
12	rs2812378	CCL21	6366
13	rs10760130	NA	NA
14	rs2900180	NA	NA
15	rs4750316	DKFZp667F0711	399716
16	rs1678542	KIF5A	3798
17	rs4810485	CD40	958