All polymorphisms studied in this paper [PMID: 21068098] , total : 11 polymorphisms

Title : Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus.

Abstract : BACKGROUND: Evidence is beginning to emerge that there may be susceptibility loci for rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) that are common to both diseases. OBJECTIVE: To investigate single nucleotide polymorphisms that have been reported to be associated with SLE in a UK cohort of patients with RA and controls. METHODS: 3962 patients with RA and 9275 controls were included in the study. Eleven SNPs mapping to confirmed SLE loci were investigated. These mapped to the TNFSF4, BANK1, TNIP1, PTTG1, UHRF1BP1, ATG5, JAZF1, BLK, KIAA1542, ITGAM and UBE2L3 loci. Genotype frequencies were compared between patients with RA and controls using the trend test. RESULTS: The SNPs mapping to the BLK and UBE2L3 loci showed significant evidence for association with RA. Two other SNPs, mapping to ATG5 and KIAA1542, showed nominal evidence for association with RA (p=0.02 and p=0.02, respectively) but these were not significant after applying a Bonferroni correction. Additionally, a significant global enrichment in carriage of SLE alleles in patients with RA compared with controls (p=9.1x10(-7)) was found. Meta-analysis of this and previous studies confirmed the association of the BLK and UBE2L3 gene with RA at genome-wide significance levels (p<5x10(-8)). Together, the authors estimate that the SLE and RA overlapping loci, excluding HLA-DRB1 alleles, identified so far explain approximately 5.8% of the genetic susceptibility to RA as a whole. CONCLUSION: The findings confirm the association of the BLK and UBE2L3 loci with RA, thus adding to the list of loci showing overlap between RA and SLE.

Author : Orozco G,Eyre S,Hinks A,Bowes J,Morgan AW,Wilson AG,Wordsworth P,Steer S,Hocking L,Thomson W,Worthington J,Barton A,

Source : Ann Rheum Dis. 2011 Mar;70(3):463-8. doi: 10.1136/ard.2010.137174. Epub 2010 Nov 10.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs10489265	LOC100506023	100506023
2	rs10516487	BANK1	55024
3	rs10036748	TNIP1	10318
4	rs2431697	NA	NA
5	rs11755393	LOC154449	154449
6	rs6568431	NA	NA
7	rs864745	JAZF1	221895
8	rs2736340	NA	NA
9	rs4963128	PHRF1	57661
10	rs9888739	ITGAM	3684
11	rs5754217	UBE2L3	7332