All polymorphisms studied in this paper [PMID: 21253737] , total : 2 polymorphisms

Title : Association of the C-285T and A5954G polymorphisms in the DNA repair gene OGG1 with the susceptibility of rheumatoid arthritis.

Abstract : Rheumatoid arthritis (RA) is a chronic autoimmune disease and can lead to deformities and severe disabilities, due to irreversible damage of tendons, joints, and bones. Previous study indicated that DNA repair system was involved in the pathology of RA. In this study, we investigated the association of two 8-oxoguanine glycosylase 1 (OGG1) gene polymorphisms (rs159153 and rs3219008) with the susceptibility to RA in 384 Taiwanese individuals (192 patients with RA and 192 controls). Our data showed that statistically significant difference in genotype frequency distributions was found at rs3219008 SNP between patients with RA and control groups (P = 5.6E-0.5). Our data also indicated that individuals with the AG genotype at rs3219008 SNP may have a higher risk of developing RA. We did not observe any statistically significant association of OGG1 haplotype frequencies (rs159153 and rs3219008) with RA progression. The study suggested that OGG1 polymorphisms (rs159153 and rs3219008) are associated with RA progression and that these may be used as molecular markers of RA.

Author : Chen SY,Wan L,Huang CM,Huang YC,Sheu JJ,Lin YJ,Liu SP,Lan YC,Lai CH,Lin CW,Tsai CH,Tsai FJ,

Source : Rheumatol Int. 2012 May;32(5):1165-9. doi: 10.1007/s00296-010-1738-1. Epub 2011 Jan 21.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs159153	BRPF1	7862
2	rs3219008	OGG1	4968