All polymorphisms studied in this paper [PMID: 21385363] , total : 18 polymorphisms

Title : Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.

Abstract : BACKGROUND: Various cytokines and inflammatory mediators are known to be involved in the pathogenesis of rheumatoid arthritis (RA). We hypothesized that polymorphisms in selected inflammatory response and tissue repair genes contribute to the susceptibility to and severity of RA. METHODS: Polymorphisms in TNFA, IL1B, IL4, IL6, IL8, IL10, PAI1, NOS2a, C1INH, PARP, TLR2 and TLR4 were genotyped in 376 Caucasian RA patients and 463 healthy Caucasian controls using single base extension. Genotype distributions in patients were compared with those in controls. In addition, the association of polymorphisms with the need for anti-TNF-alpha treatment as a marker of RA severity was assessed. RESULTS: The IL8 781 CC genotype was associated with early onset of disease. The TNFA -238 G/A polymorphism was differentially distributed between RA patients and controls, but only when not corrected for age and gender. None of the polymorphisms was associated with disease severity. CONCLUSIONS: We here report an association between IL8 781 C/T polymorphism and age of onset of RA. Our findings indicate that there might be a role for variations in genes involved in the immune response and in tissue repair in RA pathogenesis. Nevertheless, additional larger genomic and functional studies are required to further define their role in RA.

Author : Emonts M,Hazes MJ,Houwing-Duistermaat JJ,van der Gaast-de Jongh CE,de Vogel L,Han HK,Wouters JM,Laman JD,Dolhain RJ,

Source : BMC Med Genet. 2011 Mar 7;12:36. doi: 10.1186/1471-2350-12-36.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs1800795	IL6	3569
2	rs2297518	NOS2	4843
3	rs2227306	IL8	3576
4	rs1136410	PARP1	142
5	rs1799889	SERPINE1	5054
6	rs2243250	IL4	3565
7	rs1800630	TNF	7124
8	rs4926	SERPING1	710
9	rs1799724	TNF	7124
10	rs1800896	IL10	3586
11	rs3093659	TNF	7124
12	rs1800871	IL10	3586
13	rs1800629	TNF	7124
14	rs4986790	TLR4	7099
15	rs361525	TNF	7124
16	rs4986791	TLR4	7099
17	rs1143627	IL1B	3553
18	rs3021097	IL10	3586