All polymorphisms studied in this paper [PMID: 21475983] , total : 2 polymorphisms

Title : Galectin-3 gene (LGALS3) +292C allele is a genetic predisposition factor for rheumatoid arthritis in Taiwan.

Abstract : Galectin-3 is a beta-galactoside-binding lectin which is involved in modulating inflammation and apoptosis. Elevated expression of galectin-3 has been demonstrated in synovium of rheumatoid arthritis (RA). The aim of our study is to investigate the genetic polymorphisms of galectin-3 in association with RA. Polymorphisms of galectin-3 gene (LGALS3) were compared between 151 RA patients and 182 healthy subjects in Taiwan. Variants at two LGALS3 single nucleotide polymorphism (SNP) sites (rs4644 and rs4652, corresponding to LAGLS3 +191 and +292) were genotyped by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) and sequence-specific oligonucleotide probe hybridization, respectively. The allelic carriage of LGALS3 +292C was increased in patients with RA (66.9% in RA vs. 52.7% in controls, odds ratio=1.8, 95% confidence interval=1.2-2.8, p=0.009). These results implicate that the genetic polymorphisms in galectin-3 gene may contribute to development of RA.

Author : Hu CY,Chang SK,Wu CS,Tsai WI,Hsu PN,

Source : Clin Rheumatol. 2011 Sep;30(9):1227-33. doi: 10.1007/s10067-011-1741-2. Epub 2011 Apr 8.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs4644	LGALS3	3958
2	rs4652	LGALS3	3958