All polymorphisms studied in this paper [PMID: 21497535] , total : 2 polymorphisms

Title : Association of interleukin-4 receptor gene polymorphisms with rheumatoid arthritis in Egyptian female patients.

Abstract : OBJECTIVES: The imbalance between proinflammatory and anti-inflammatory cytokines is a feature of rheumatoid arthritis (RA). The role of interleukin-4 (IL-4) and its receptor in the pathogenesis of RA is conflicting. We aim to investigate the role of polymorphisms in the IL-4Ralpha gene in susceptibility and severity of RA. METHODS: One hundred and seventy-two RA patients and 172 controls were enrolled in the study. Genotyping of IL-4Ralpha I50V (rs1805010) and IL-4Ralpha Q576R (rs1801275) was determined by restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP). RESULTS: IL-4Ralpha I50V genotype was significantly more frequent in patients with RA than in controls (OR: 1.97, 95% CI: 1-3.7, P: 0.035). Subjects with IL-4Ralpha V50V genotype were significantly more likely to have erosive arthropathy (OR: 2.6, 95% CI: 1.1-6.1, P: 0.02). The frequencies of IL-4Ralpha Q576R genotype were significantly decreased in patients with erosive RA compared to patients with nonerosive RA (31.6% versus 48.2%, OR: 2.7, 95% CI: 1-7.7, P: 0.04). CONCLUSION: IL-4Ralpha polymorphisms were associated with susceptibility to RA and may be helpful in early detection of erosive RA.

Author : Hussein Y,El-Tarhouny S,Mohamed R,Pasha H,Abul-Saoud A,

Source : Joint Bone Spine. 2012 Jan;79(1):38-42. doi: 10.1016/j.jbspin.2011.02.017. Epub 2011 Apr 15.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs1805010	IL4R	3566
2	rs1801275	IL4R	3566