All polymorphisms studied in this paper [PMID: 21565238] , total : 6 polymorphisms

Title : T-cell immunoglobulin and mucin domain 3 genetic polymorphisms are associated with rheumatoid arthritis independent of a shared epitope status.

Abstract : The aim of this study was to investigate T-cell immunoglobulin and mucin domain 3 (TIM3) genetic polymorphisms and rheumatoid arthritis (RA) according to the shared epitope (SE) status. Six single nucleotide polymorphisms (SNPs: rs11742259 [C/T], rs10515746 [C/A], rs35960726 [A/G], rs1036199 [A/C], rs4704846 [A/G], and rs11134551 [A/G]) in the TIM3 gene from 366 RA patients and 389 healthy controls were investigated using the real-time polymerase chain reaction method. Associations between these SNPs and clinical manifestations (including SE status) were investigated using the SPSS program and Haploview. Polymorphisms of rs35690726 (AG+ GG vs AA: 8.2% vs 1.8%, p(c) < 0.001) were significantly associated with RA with or without SE (p(c) < 0.001 or p(c) = 0.009, respectively). Polymorphisms of rs11742259 (p(c) = 0.003) and rs1036199 (p(c) = 0.012) were significantly different in RA patients with SE, but not in those without SE. In haplotype analysis with a permutation test for the first 4 SNPs (rs11742259, rs10515746, rs35690726, and, rs1036199), CCAA, CCGA, CCGC, and CAAA haplotypes were significantly associated with RA. The clinical characteristics of RA patients were not significantly associated with any TIM3 polymorphism. TIM3 genetic polymorphisms may have a role in the development of RA regardless of a shared epitope status.

Author : Song YW,Im CH,Park JH,Lee YJ,Lee EY,Lee EB,Park K,

Source : Hum Immunol. 2011 Aug;72(8):652-5. doi: 10.1016/j.humimm.2011.04.007. Epub 2011 Apr 28.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs11742259	NA	NA
2	rs10515746	HAVCR2	84868
3	rs35960726	HAVCR2	84868
4	rs1036199	HAVCR2	84868
5	rs4704846	HAVCR2	84868
6	rs11134551	NA	NA