All polymorphisms studied in this paper [PMID: 21614018] , total : 22 polymorphisms
| Title : Non-HLA genes modulate the risk of rheumatoid arthritis associated with HLA-DRB1 in a susceptible North American Native population. |
| Abstract : Most of the genetic risk for rheumatoid arthritis (RA) is conferred by 'shared epitope' (SE), encoding alleles of HLA-DRB1. Specific North American Native (NAN) populations have RA prevalence rates of 2-5%, representing some of the highest rates estimated worldwide. As many NAN populations also demonstrate a high background frequency of SE, we sought to determine whether other genetic factors contribute to disease risk in this predisposed population. RA patients (n=333) and controls (n=490) from the Cree/Ojibway NAN population in Central Canada were HLA-DRB1 typed and tested for 21 single-nucleotide polymorphisms (SNPs) that have previously been associated with RA, including PTPN22, TRAF1-C5, CTLA4, PADI4, STAT4, FCRL3, CCL21, MMEL1-TNFRSF14, CDK6, PRKCQ, KIF5A-PIP4K2C, IL2RB, TNFAIP3, IL10-1082G/A and REL. Our findings indicate that SE is prevalent and represents a major genetic risk factor for RA in this population (82% cases versus 68% controls, odds ratio=2.2, 95% confidence interval 1.6-3.1, P<0.001). We also demonstrate that in the presence of SE, the minor allele of MMEL1-TNFRSF14 significantly reduces RA risk in a dominant manner, whereas TRAF1-C5 increases the risk. These findings point to the importance of non-HLA genes in determining RA risk in a population with a high frequency of disease predisposing HLA-DRB1 alleles. |
| Author : El-Gabalawy HS,Robinson DB,Daha NA,Oen KG,Smolik I,Elias B,Hart D,Bernstein CN,Sun Y,Lu Y,Houwing-Duistermaat JJ,Siminovitch KA, |
| Source : Genes Immun. 2011 Oct;12(7):568-74. doi: 10.1038/gene.2011.30. Epub 2011 May 26. |
22 records 1/1 page
| No. | Polymorphism name | Gene Symbol | Entrez Gene ID |
|---|---|---|---|
| 1 | rs3890745 | MMEL1 | 79258 |
| 2 | rs2240340 | PADI4 | 23569 |
| 3 | rs6679677 | PHTF1 | 10745 |
| 4 | rs2476601 | PTPN22 | 26191 |
| 5 | rs11264799 | FCRL3 | 115352 |
| 6 | rs7528684 | FCRL3 | 115352 |
| 7 | rs1800896 | IL10 | 3586 |
| 8 | rs702873 | LINC01185 | 400957 |
| 9 | rs13031237 | REL | 5966 |
| 10 | rs3024921 | STAT4 | 6775 |
| 11 | rs7574865 | STAT4 | 6775 |
| 12 | rs3087243 | CTLA4 | 1493 |
| 13 | rs6748358 | NA | NA |
| 14 | rs10499194 | NA | NA |
| 15 | rs6920220 | NA | NA |
| 16 | rs42041 | CDK6 | 1021 |
| 17 | rs2812378 | CCL21 | 6366 |
| 18 | rs3761847 | TRAF1 | 7185 |
| 19 | rs10818488 | NA | NA |
| 20 | rs4750316 | DKFZp667F0711 | 399716 |
| 21 | rs1678542 | KIF5A | 3798 |
| 22 | rs3218253 | IL2RB | 3560 |
22 records 1/1 page
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