All polymorphisms studied in this paper [PMID: 21807777] , total : 1 polymorphisms

Title : Preferential association of interferon regulatory factor 5 gene variants with seronegative rheumatoid arthritis in 2 Swedish case-control studies.

Abstract : OBJECTIVE: Two interferon regulatory factor 5 (IRF5) gene variants were examined for association with rheumatoid arthritis (RA). METHODS: A total of 2300 patients with RA and 1836 controls were recruited from 2 independent RA studies in Sweden. One insertion-deletion polymorphism (CGGGG indel) and one single-nucleotide polymorphism (rs10488631) in the IRF5 gene were genotyped and analyzed within RA subgroups stratified by rheumatoid factor (RF) and anticitrullinated peptide antibodies (ACPA). RESULTS: The CGGGG indel was preferentially associated with the RF-negative (OR 1.29, p = 7.9 x 10(-5)) and ACPA-negative (OR 1.27, p = 7.3 x 10(-5)) RA subgroups compared to the seropositive counterparts. rs10488631 was exclusively associated within the seronegative RA subgroups (RF-negative: OR 1.24, p = 0.016; ACPA-negative: OR 1.27, p = 4.1 x 10(-3)). CONCLUSION: Both the CGGGG indel and rs10488631 are relevant for RA susceptibility, especially for seronegative RA.

Author : Wang C,Kokkonen H,Sandling JK,Johansson M,Seddighzadeh M,Padyukov L,Rantapaa-Dahlqvist S,Syvanen AC,

Source : J Rheumatol. 2011 Oct;38(10):2130-2. doi: 10.3899/jrheum.110322. Epub 2011 Aug 1.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs10488631	TNPO3	23534