All polymorphisms studied in this paper [PMID: 21833526] , total : 1 polymorphisms

Title : A Tunisian case-control association study of a 6q polymorphism in rheumatoid arthritis.

Abstract : Rheumatoid arthritis (RA), the most common autoimmune inflammatory disease of the joints, is a multifactorial disease, involving both genetic and environmental risk factors. TNFAIP3 (tumor necrosis factor, alpha-induced protein 3) gene located in a region of genetic susceptibility in RA is an attractive candidate to be involved in autoimmunity disorders. Our aim was to test the single nucleotide polymorphism rs6920220 located near TNFAIP3 in a case-control study in Tunisian population. The rare allele rs6920220-A was reported to have a risk effect on RA in several genome-wide association studies. Our results revealed a trend of an association of rs6920220-A allele with RA and genotypes containing this allele were in a higher proportion in RA patients than in matched controls. These findings have to be confirmed by a replication in largest RA and control groups of the same ethnic origin. TNFAIP3 gene may have a key role in autoimmunity through its action as a negative regulator of the NF-kappaB pathway. Further functional investigations are required to understand the mechanism by which this gene is involved in the RA pathogenesis.

Author : Ben Hamad M,Cornelis F,Maalej A,Petit-Teixeira E,

Source : Rheumatol Int. 2012 Jun;32(6):1849-50. doi: 10.1007/s00296-011-1996-6. Epub 2011 Jul 22.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs6920220	NA	NA