All polymorphisms studied in this paper [PMID: 21844665] , total : 11 polymorphisms

Title : Common variants at the promoter region of the APOM confer a risk of rheumatoid arthritis.

Abstract : Although the genetic component in the etiology of rheumatoid arthritis (RA) has been consistently suggested, many novel genetic loci remain to uncover. To identify RA risk loci, we performed a genome-wide association study (GWAS) with 100 RA cases and 600 controls using Affymetrix SNP array 5.0. The candidate risk locus (APOM gene) was re-sequenced to discover novel promoter and coding variants in a group of the subjects. Replication was performed with the independent case-control set comprising of 578 RAs and 711 controls. Through GWAS, we identified a novel SNP associated with RA at the APOM gene in the MHC class III region on 6p21.33 (rs805297, odds ratio (OR) = 2.28, P = 5.20 x 10-7). Three more polymorphisms were identified at the promoter region of the APOM by the re-sequencing. For the replication, we genotyped the four SNP loci in the independent case-control set. The association of rs805297 identified by GWAS was successfully replicated (OR = 1.40, P = 6.65 x 10-5). The association became more significant in the combined analysis of discovery and replication sets (OR = 1.56, P = 2.73 x 10-10). The individuals with the rs805297 risk allele (A) at the promoter region showed a significantly lower level of APOM expression compared with those with the protective allele (C) homozygote. In the logistic regressions by the phenotype status, the homozygote risk genotype (A/A) consistently showed higher ORs than the heterozygote one (A/C) for the phenotype-positive RAs. These results indicate that APOM promoter polymorphisms are significantly associated with the susceptibility to RA.

Author : Hu HJ,Jin EH,Yim SH,Yang SY,Jung SH,Shin SH,Kim WU,Shim SC,Kim TG,Chung YJ,

Source : Exp Mol Med. 2011 Nov 30;43(11):613-21. doi: 10.3858/emm.2011.43.11.068.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs17027492	NA	NA
2	rs6081341	DTD1	92675
3	rs805297	APOM	55937
4	rs12642867	NA	NA
5	rs11228951	NA	NA
6	rs2241520	NA	NA
7	rs1445289	NA	NA
8	rs7114828	MAML2	84441
9	rs1266078	BAG6	7917
10	rs9404941	APOM	55937
11	rs805296	APOM	55937