All polymorphisms studied in this paper [PMID: 22365150] , total : 13 polymorphisms

Title : Use of a multiethnic approach to identify rheumatoid loci, 1p36 and 17q12.

Abstract : We have previously shown that rheumatoid arthritis (RA) risk alleles overlap between different ethnic groups. Here, we utilize a multiethnic approach to show that we can effectively discover RA risk alleles. Thirteen putatively associated SNPs that had not yet exceeded genome-wide significance (p < 5 x 10(-8)) in our previous RA genome-wide association study (GWAS) were analyzed in independent sample sets consisting of 4,366 cases and 17,765 controls of European, African American, and East Asian ancestry. Additionally, we conducted an overall association test across all 65,833 samples (a GWAS meta-analysis plus the replication samples). Of the 13 SNPs investigated, four were significantly below the study-wide Bonferroni corrected p value threshold (p < 0.0038) in the replication samples. Two SNPs (rs3890745 at the 1p36 locus [p = 2.3 x 10(-12)] and rs2872507 at the 17q12 locus [p = 1.7 x 10(-9)]) surpassed genome-wide significance in all 16,659 RA cases and 49,174 controls combined. We used available GWAS data to fine map these two loci in Europeans and East Asians, and we found that the same allele conferred risk in both ethnic groups. A series of bioinformatic analyses identified TNFRSF14-MMEL1 at the 1p36 locus and IKZF3-ORMDL3-GSDMB at the 17q12 locus as the genes most likely associated with RA. These findings demonstrate empirically that a multiethnic approach is an effective strategy for discovering RA risk loci, and they suggest that combining GWASs across ethnic groups represents an efficient strategy for gaining statistical power.

Author : Kurreeman FA,Stahl EA,Okada Y,Liao K,Diogo D,Raychaudhuri S,Freudenberg J,Kochi Y,Patsopoulos NA,Gupta N,Sandor C,Bang SY,Lee HS,Padyukov L,Suzuki A,Siminovitch K,Worthington J,Gregersen PK,Hughes LB,Reynolds RJ,Bridges SL Jr,Bae SC,Yamamoto K,Plenge RM,

Source : Am J Hum Genet. 2012 Mar 9;90(3):524-32. doi: 10.1016/j.ajhg.2012.01.010. Epub 2012 Feb 23.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs3890745	MMEL1	79258
2	rs7543174	UBE2Q1	55585
3	rs12746613	NA	NA
4	rs10919563	PTPRC	5788
5	rs13119723	KIAA1109	84162
6	rs11594656	NA	NA
7	rs2793108	NA	NA
8	rs540386	TRAF6	7189
9	rs3184504	SH2B3	10019
10	rs8045689	SPNS1	83985
11	rs2872507	NA	NA
12	rs11203203	UBASH3A	53347
13	rs5754217	UBE2L3	7332