All polymorphisms studied in this paper [PMID: 23505228] , total : 1 polymorphisms

Title : The 158VV Fcgamma receptor 3A genotype is associated with response to rituximab in rheumatoid arthritis: results of an Italian multicentre study.
Abstract : OBJECTIVE: The polymorphism 158V/F of Fc fragment of IgG (FCGR) type 3A may influence the response to rituximab (RTX) in rheumatoid arthritis (RA). We investigated the FCG3A polymorphism in a large cohort of RA patients treated with RTX, also by considering the possible loss of response from month +4 to +6 after RTX and the presence of established predictors of response. METHODS: The study analysed 212 RA patients. European League Against Rheumatism (EULAR) response was evaluated at months +4 and +6 after the first RTX infusion. The FCGR3A polymorphism was analysed by PCR followed by Sanger sequencing. RESULTS: The FCGR3A genotypes were associated with EULAR response (good or moderate) at month +6 (response in 34/38 (89.5%) VV vs 70/106 (66%) VF and in 51/77 (66.2%) FF patients; p=0.01), but not at month +4 (response in 32/37 (86.5%) VV vs 69/102 (67.6%) VF and 53/73 (72.6%) FF patients; p=0.09). Loss of response was observed only in VF and FF carriers ((VV vs VF vs FF: 0/37 (0%) vs 11/102 (10.8%) vs 12/73 (16.4%); p=0.02)). Probability of response at month +6 was very high when at least two of the three following items selected by multivariate analysis were present: positive rheumatoid factor and/or anticyclic citrullinated peptide antibodies, previous treatment with
Author : Quartuccio L,Fabris M,Pontarini E,Salvin S,Zabotti A,Benucci M,Manfredi M,Biasi D,Ravagnani V,Atzeni F,Sarzi-Puttini P,Morassi P,Fischetti F,Tomietto P,Bazzichi L,Saracco M,Pellerito R,Cimmino M,Schiavon F,Carraro V,Semeraro A,Caporali R,Cavagna L,Bortolotti R,Paolazzi G,Govoni M,Bombardieri S,De Vita S,
Source : Ann Rheum Dis. 2014 Apr;73(4):716-21. doi: 10.1136/annrheumdis-2012-202435. Epub 2013 Mar 16.
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No.Polymorphism nameGene SymbolEntrez Gene ID
1 rs396991 FCGR3A 2214
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