All polymorphisms studied in this paper [PMID: 23568741] , total : 5 polymorphisms

Title : [Association between polymorphisms of PSMB8, PSMB9 and TAP2 genes with rheumatoid arthritis in ethnic Han Chinese from Yunnan].

Abstract : OBJECTIVE: To assess the association between single nucleotide polymorphisms (SNPs) of PSMB8, PSMB9 and TAP2 genes and rheumatoid arthritis (RA) in ethnic Han Chinese from Yunnan. METHODS: A case-control study was carried out using 177 RA patients and 288 healthy controls. Genotypes of rs2071543, rs55745125 and rs138635403 loci of PSMB8 gene, and rs17587 locus of PSMB9 gene were determined with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). And a polymerase chain reaction amplification refractory mutation system (ARMS-PCR) was used for typing rs2228396 locus of TAP2 gene. Genotypic and allelic frequencies were calculated. An Epi Info 7 software was used to calculate the Odds Ratio (OR) of above SNPs between the two groups. RESULTS: Allelic and genotypic frequencies of rs138635403 and rs17587 loci have differed significantly between the two groups (P<0.05). The frequency of GG genotype for rs17587 locus was also higher in the RA group (0.672) compared with control group (0.524) (OR=1.862, 95%CI: 1.261-2.749). CONCLUSION: Genetic polymorphisms of rs17587 appeared to be associated with RA in ethnic Han Chinese from Yunnan.

Author : Yu L,Li Q,Lin J,Yu J,Li Q,Yi W,Sun H,Chu JY,Yang ZQ,

Source : Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2013 Apr;30(2):222-6. doi: 10.3760/cma.j.issn.1003-9406.2013.04.023.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs2071543	PSMB8	5696
2	rs55745125	PSMB8	5696
3	rs138635403	PSMB8	5696
4	rs17587	PSMB9	5698
5	rs2228396	TAP2	6891