All polymorphisms studied in this paper [PMID: 23651021] , total : 3 polymorphisms

Title : GWAS replication study confirms the association of PDE3A-SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis.

Abstract : AIM: The present study was undertaken to replicate the association of candidate genes for anti-TNF response in rheumatoid arthritis. Candidate genes were selected from a recent genome-wide association study on anti-TNF response performed in a population from Denmark. MATERIALS & METHODS: Genomic DNA was obtained from 315 Spanish rheumatoid arthritis patients having received an anti-TNF agent as their first biological therapy. SNPs from NR2FR2, MAP2K6, CBLN2 and PDE3A-SLCO1C1 candidate loci were genotyped. RESULTS: The PDE3A-SLCO1C1 locus rs3794271 SNP showed a highly significant association with anti-TNF treatment response (p = 1.74 x 10(-)(5)). Combining the statistical evidence from the Spanish and Danish rheumatoid arthritis cohorts, the associated rs3794271 SNP reached a genome-wide significance level of association (p = 3.3 x 10(-)(1)(0)). CONCLUSION: The present findings establish the PDE3A-SLCO1C1 locus as a strong genetic marker of anti-TNF therapy response.

Author : Acosta-Colman I,Palau N,Tornero J,Fernandez-Nebro A,Blanco F,Gonzalez-Alvaro I,Canete JD,Maymo J,Ballina J,Fernandez-Gutierrez B,Olive A,Corominas H,Erra A,Canela-Xandri O,Alonso A,Lopez Lasanta M,Tortosa R,Julia A,Marsal S,

Source : Pharmacogenomics. 2013 May;14(7):727-34. doi: 10.2217/pgs.13.60.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs3794271	SLCO1C1	53919
2	rs10520789	NA	NA
3	rs11870477	LOC101928122	101928122