All polymorphisms studied in this paper [PMID: 23933633] , total : 11 polymorphisms

Title : Association of forkhead box J3 (FOXJ3) polymorphisms with rheumatoid arthritis.

Abstract : The aim of this study was to investigate the correlation between single nucleotide polymorphisms (SNPs) of the forkhead box J3 (FOXJ3) gene and rheumatoid arthritis (RA). For the association studies, 307 patients with RA and 476 control patients without RA were recruited. Eleven SNPs (rs2282404, rs2455084, rs1393009, rs7539485, rs4660616, rs510157, rs343386, rs12732892, rs343389, rs343376 and rs585320) were genotyped using direct sequencing and the resulting data were analyzed using the SNPStats, Haploview and Helixtree programs. Seven SNPs (rs2455084, rs1393009, rs7539485, rs4660616, rs510157, rs343386 and rs343389) were associated with RA in three alternative models (logadditive, dominant and recessive models; P<0.05). A strong linkage disequilibrium block, including all 11 SNPs, was constructed using the Gabriel method. Two haplotypes, TCCTTGTCTTT and TCTTCTGTCAC, were significantly associated with RA (P<0.05). In clinical characteristic analysis, the SNP rs585320 was also associated with the anticyclic citrullinated peptide. These results suggest that FOXJ3 may be associated with the development of RA.

Author : Ban JY,Park HJ,Kim SK,Kim JW,Lee YA,Choi IA,Chung JH,Hong SJ,

Source : Mol Med Rep. 2013 Oct;8(4):1235-41. doi: 10.3892/mmr.2013.1623. Epub 2013 Aug 9.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs2282404	FOXJ3	22887
2	rs2455084	FOXJ3	22887
3	rs1393009	FOXJ3	22887
4	rs7539485	FOXJ3	22887
5	rs4660616	FOXJ3	22887
6	rs510157	FOXJ3	22887
7	rs343386	FOXJ3	22887
8	rs12732892	FOXJ3	22887
9	rs343389	FOXJ3	22887
10	rs343376	FOXJ3	22887
11	rs585320	FOXJ3	22887