All polymorphisms studied in this paper [PMID: 24315820] , total : 1 polymorphisms

Title : Interaction between TGF-beta1 (869C/T) polymorphism and biochemical risk factor for prediction of disease progression in rheumatoid arthritis.

Abstract : OBJECTIVES: Rheumatoid arthritis (RA) is a chronic inflammatory disease. Transforming growth factor-beta1 (TGF-beta1) may be a promising candidate gene for susceptibility and severity in RA. We aimed to determine whether TGF-beta1 polymorphism is associated with susceptibility to RA and progression of joint destruction, as well as to identify the interaction between TGF-beta1 polymorphism and biochemical risk factor. METHODS: A total of 160 RA patients and 168 healthy unrelated controls were tested for the TGF-beta1 (869C/T) polymorphism using polymerase chain reaction. RESULTS: The TGF-beta1 T allele was associated with susceptibility to RA. Within the RA group, TGF-beta1 T allele carriers had a significant increased risk to develop osteoporosis (OR=4.4, 95% CI=-2. 4-8.1, P<0.001), as well as more likely to develop bone erosion (OR=1.7, 95% CI=0. 99-2.7, P=0. 034). Better prediction was achieved when the TGF-beta1 TT genotype was used in combination with either elevated, rheumatoid factor (RF) or C-reactive protein (CRP) (OR=6.8, 3.7 respectively). Also, they increased the risk to develop bone erosion in patients with rheumatoid arthritis (OR=3.3, 9.8, P=0.017, 0.001 respectively). CONCLUSION: Our results suggest that TGF-beta1 TT genotype may determine the development of osteoporosis and bone erosion in RA. Also, our results points to a synergism between TGF-beta1 TT genotype and elevated serum RF or elevated CRP that lead to the development of osteoporosis and bone erosion in patients with rheumatoid arthritis.

Author : Hussein YM,Mohamed RH,El-Shahawy EE,Alzahrani SS,

Source : Gene. 2014 Feb 25;536(2):393-7. doi: 10.1016/j.gene.2013.11.042. Epub 2013 Dec 4.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs1982073	TGFB1	7040