All polymorphisms studied in this paper [PMID: 24382334] , total : 2 polymorphisms

Title : The association between TNFalpha gene polymorphisms and susceptibility to rheumatoid arthritis in an ethnic Kashmiri population: relationship with disease activity and severity markers.

Abstract : AIM: The aim of our study was to determine the genetic associations between polymorphisms of the TNFalpha gene (-308G/A and -238G/A) with disease susceptibility and severity in patients with rheumatoid arthritis (RA) in an ethnic Kashmiri population. METHODS: Allele and genotype frequencies of TNFalpha-308G/A and TNFalpha-238G/A polymorphisms were compared between 150 RA patients and 200 healthy controls by using polymerase chain reaction - restriction fragment length polymorphism method. Demographic, clinical and serological data were prospectively evaluated. Disease activity score (DAS28) was also assessed. RESULTS: We did not find any significant association between TNFalpha-308G/A and TNFalpha-238G/A polymorphism and RA risk (P > 0.05), but TNFalpha-308GG genotype was associated significantly with rheumatoid factor seropositivity (P < 0.01) and TNFalpha-238GA genotype was associated with swollen joint count < 5 (P = 0.04) as well as with less severe disease activity as measured by DAS28 score (P = 0.02). CONCLUSION: Our findings suggest the possible roles of TNFalpha-308GG and TNFalpha-238GA as important determinants for the development of certain manifestations and disease severity in RA in ethnic Kashmiri population.

Author : Shafia S,Sofi FA,Dilafroze,Rasool R,Javeed S,Shah ZA,

Source : Int J Rheum Dis. 2013 Dec 30. doi: 10.1111/1756-185X.12270.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs1800629	TNF	7124
2	rs361525	TNF	7124