All polymorphisms studied in this paper [PMID: 24532676] , total : 8 polymorphisms

Title : High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.

Abstract : OBJECTIVE: A highly polygenic aetiology and high degree of allele-sharing between ancestries have been well elucidated in genetic studies of rheumatoid arthritis. Recently, the high-density genotyping array Immunochip for immune disease loci identified 14 new rheumatoid arthritis risk loci among individuals of European ancestry. Here, we aimed to identify new rheumatoid arthritis risk loci using Korean-specific Immunochip data. METHODS: We analysed Korean rheumatoid arthritis case-control samples using the Immunochip and genome-wide association studies (GWAS) array to search for new risk alleles of rheumatoid arthritis with anticitrullinated peptide antibodies. To increase power, we performed a meta-analysis of Korean data with previously published European Immunochip and GWAS data for a total sample size of 9299 Korean and 45 790 European case-control samples. RESULTS: We identified eight new rheumatoid arthritis susceptibility loci (TNFSF4, LBH, EOMES, ETS1-FLI1, COG6, RAD51B, UBASH3A and SYNGR1) that passed a genome-wide significance threshold (p<5x10-8), with evidence for three independent risk alleles at 1q25/TNFSF4. The risk alleles from the seven new loci except for the TNFSF4 locus (monomorphic in Koreans), together with risk alleles from previously established RA risk loci, exhibited a high correlation of effect sizes between ancestries. Further, we refined the number of single nucleotide polymorphisms (SNPs) that represent potentially causal variants through a trans-ethnic comparison of densely genotyped SNPs. CONCLUSIONS: This study demonstrates the advantage of dense-mapping and trans-ancestral analysis for identification of potentially causal SNPs. In addition, our findings support the importance of T cells in the pathogenesis and the fact of frequent overlap of risk loci among diverse autoimmune diseases.

Author : Kim K,Bang SY,Lee HS,Cho SK,Choi CB,Sung YK,Kim TH,Jun JB,Yoo DH,Kang YM,Kim SK,Suh CH,Shim SC,Lee SS,Lee J,Chung WT,Choe JY,Shin HD,Lee JY,Han BG,Nath SK,Eyre S,Bowes J,Pappas DA,Kremer JM,Gonzalez-Gay MA,Rodriguez-Rodriguez L,Arlestig L,Okada Y,Diogo D,Liao KP,Karlson EW,Raychaudhuri S,Rantapaa-Dahlqvist S,Martin J,Klareskog L,Padyukov L,Gregersen PK,Worthington J,Greenberg JD,Plenge RM,Bae SC,

Source : Ann Rheum Dis. 2014 Feb 14. doi: 10.1136/annrheumdis-2013-204749.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs1893592	UBASH3A	53347
2	rs4936059	NA	NA
3	rs61828284	LOC100506023	100506023
4	rs909685	SYNGR1	9145
5	rs7579944	NA	NA
6	rs9603618	NA	NA
7	rs911263	RAD51B	5890
8	rs9880772	NA	NA