All polymorphisms studied in this paper [PMID: 24707478] , total : 2 polymorphisms

Title : The effects of gene polymorphisms in interleukin-4 and interleukin-6 on the susceptibility of rheumatoid arthritis in a chinese population.

Abstract : Background. Interleukin-4 (IL-4) and interleukin-6 (IL-6) have been reported to associate with pathogenesis of rheumatoid arthritis (RA); however, the role of IL-4 and IL-6 genetic polymorphisms in RA remains unknown. Method. A total of 752 unrelated Chinese patients with RA and 798 healthy Chinese volunteers with no family histories of any autoimmune diseases were recruited. The promoter IL-4-590 C/T and IL-6-174 G/C polymorphisms were genotyped. Result. The genotype distributions and allele frequencies of IL-4-590 C/T and IL-6-174 G/C polymorphisms in RA patients were significantly different from healthy volunteers. Statistically significant differences were observed in genotypes for IL-4-590 and IL-6-174. The frequencies of both the T allele on the IL-4-590 and the C on the IL-6-174 were significantly increased in RA patients. Conclusion. The IL-4-590 and IL-6-174 promoter polymorphisms may be associated with increased risk of RA and could be used as genetic marker for assessing the susceptibility and severity of RA in Chinese.

Author : Li X,Chai W,Ni M,Xu M,Lian Z,Shi L,Bai Y,Wang Y,

Source : Biomed Res Int. 2014;2014:265435. doi: 10.1155/2014/265435. Epub 2014 Feb 23.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs2243250	IL4	3565
2	rs1800795	IL6	3569