All polymorphisms studied in this paper [PMID: 9536820] , total : 20 polymorphisms

Title : Analysis of LMP and TAP polymorphisms by polymerase chain reaction-restriction fragment length polymorphism in rheumatoid arthritis.

Abstract : OBJECTIVE: The aim of this study was to investigate the relation between the polymorphism of large molecular weight proteasome (LMP) (LMP2-LMP7) and transporter associated with antigen processing (TAP) (TAP1-TAP2) genes and rheumatoid arthritis (RA). METHODS: Sixty RA patients and 102 ethnically matched unrelated healthy subjects were typed for LMP, TAP, and disease associated HLA-DRB1 alleles by using a new strategy based on polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with amplification created restriction sites. RESULTS: The polymorphism of LMP (LMP2-LMP7) and TAP (TAP1-TAP2) genes was examined in shared epitope positive and negative RA patients and controls. No significant differences in the LMP or TAP allele frequencies were observed between the total patient and control groups or the patients and controls groups or the patients and controls positive or negative for the shared epitope. CONCLUSION: The data suggest that the polymorphisms of LMP and TAP genes do not have an important influence in the pathogenesis of RA, although larger studies will be needed to provide more conclusive evidence on the role of these genes in RA. A new, highly reliable strategy for typing LMP alleles is also described.

Author : Vinasco J,Fraile A,Nieto A,Beraun Y,Pareja E,Mataran L,Martin J,

Source : Ann Rheum Dis. 1998 Jan;57(1):33-7.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	NA	PSMB9	5698
2	NA	PSMB8	5696
3	NA	TAP1	6890
4	NA	TAP1	6890
5	NA	TAP1	6890
6	NA	TAP1	6890
7	NA	TAP1	6890
8	NA	TAP1	6890
9	NA	TAP1	6890
10	NA	TAP2	6891
11	NA	TAP2	6891
12	NA	TAP2	6891
13	NA	TAP2	6891
14	NA	TAP2	6891
15	NA	TAP2	6891
16	NA	TAP2	6891
17	NA	TAP2	6891
18	NA	TAP2	6891
19	NA	TAP2	6891
20	NA	TAP2	6891