All polymorphisms studied in this paper [PMID: 9783765] , total : 3 polymorphisms

Title : Interleukin-10 promoter polymorphisms in rheumatoid arthritis and Felty's syndrome.

Abstract : OBJECTIVE: To examine whether promoter polymorphisms associated with variation in interleukin-10 (IL-10) production are relevant to the development of rheumatoid arthritis (RA) or Felty's syndrome (FS). METHODS: DNA was obtained from 44 FS patients, 117 RA patients and 295 controls. The promoter region between -533 and - 1120 was amplified by polymerase chain reaction, and polymorphisms detected by restriction enzyme digest or sequence-specific oligonucleotide probing. RESULTS: We found no significant difference in allele or haplotype frequencies between the groups. CONCLUSION: There is no association between FS or RA and these recently identified IL-10 promoter polymorphisms. Other genetic or environmental factors could explain the alterations in IL-10 levels seen in these conditions.

Author : Coakley G,Mok CC,Hajeer AH,Ollier WE,Turner D,Sinnott PJ,Hutchinson IV,Panayi GS,Lanchbury JS,

Source : Br J Rheumatol. 1998 Sep;37(9):988-91.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs1800896	IL10	3586
2	rs1800871	IL10	3586
3	NA	IL10	3586